Cortizone 10 overnight itch relief contains cortisone to stop itch. Melatonin and other antioxidants, plus Lavender scent to calm & soothe itch while you sleep. Fast acting and lasts 10 hours so you can sleep through the night without itch Stop the itch with Cortizone: bug bites? Allergic to your jewelry? Is dry winter skin driving you batty? Besides the irritation & pain of itchy skin, scratching can cause scaring or infections. Cortizone creams help reduce itchiness, for relief & healing. Cortizone brings fast itch relief: Cortizone creams & ointments use hydrocortisone to help relieve itching associated with minor skin irritations, inflammation, & rashes from poison ivy, oak & sumac, insects bites, eczema, psoriasis, & Contact dermatitis.