4.8-ounce tube of Desitin Daily Defense Diaper Rash Cream works from the first use to help soothe, treat and prevent diaper rash From the #1 choice for diaper rash relief by Pediatricians and parents, this infant diaper cream instantly forms a protective layer on your baby's skin for diaper rash relief and prevention Made with zinc oxide, its fast-acting hypoallergenic formula helps seal out wetness to treat diaper rash from the first signs and is clinically shown to provide diaper rash relief